TACTIC Publications

Clinical assessment of trauma-induced coagulopathy and its contribution to postinjury mortality: A TACTIC proposal. Neal, Mathew D. MD; Moore, Hunter B. MD; Moore, Ernest E. MD; Freeman, Kalev MD; Cohen, Mitchell J. MD; Sperry, Jason L. MD, MPH; Zuckerbraun, Brian S. MD; Park, Myung S. MD; TACTIC Investigators – http://journals.lww.com/jtrauma/Fulltext/2015/09000/Clinical_assessment_of_trauma_induced_coagulopathy.24.aspx

FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow. Blood. 2015 Sep 17;126(12):1494-502. doi: 10.1182/blood-2015-04-641472. Epub 2015 Jul 1. Zhu S1, Travers RJ2, Morrissey JH2, Diamond SL1.

The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury. Howard BM1, Miyazawa BY, Dong W, Cedron WJ, Vilardi RF, Ruf W, Cohen MJ.

Developing individualized coagulation profiling of disease risk: thrombin generation dynamic models of the pro and anticoagulant balance. Brummel Ziedins KE. Thromb Res. 2014; 133 Suppl 1: S9-S11.

Models for thrombin generation and risk of disease. Brummel Ziedins K. – J Thromb Haemost. 2013; 11 Suppl 1: 212-23.

COMBAT: Initial experience with a randomized clinical trial of plasma based resuscitation in the field for traumatic hemorrhagic shock. Chapman MP, Moore EE, Chin TL, Ghasabyan A, Chandler J, Stringham J, Gonzalez E, Moore HB, Banerjee A, Silliman CC, Sauaia A.. Shock. 2015 (epub ahead of print).

Polyphosphate accelerates factor V activation by factor. XIa.Choi SH, Smith SA, Morrissey JH: Thromb Haemost. 2015; 113: 599-604.

P2X7 receptor signaling contributes to tissue factor dependent thrombosis in mice. Furlan Freguia C, Marchese P, Gruber A, Ruggeri ZM, Ruf W. J Clin Invest 2011;121:2932-44.

Misled by TEG? The effects of alcohol on coagulation in trauma patients. Howard BM, Kornblith LZ, Kutcher ME, Redick BJ, Vilardi RF, Crane JM, Nelson MF, Callcut RA, Cohen MJ. J. Trauma Acute Care Surg. 2014 Dec;77(6):865-71. 2014 Aug 5.

Kinetics and role of plasma matrix metalloproteinase 9 expression in acute lung injury and the acute respiratory distress syndrome. Hsu, A.T., Barrett, C.D., DeBusk M.G., Ellson, C.D., Gautam, S., Talmor, D.S., Gallagher, D.C., and Yaffe, M.B Shock (in press).

Obesity and Clotting: Body mass index independently contributes to hypercoagulability after injury. Kornblith LZ, Howard B, Kunitake R, Redick B, Nelson M, Cohen MJ, Callcut R. J Trauma Acute Care Surg. 2015 Jan;78(1):30-8

The whole is greater than the sum of its parts: Hemostatic profiles of whole blood variants. Kornblith LZ, Cheung CK, Dayter Y, Pandey S, MP Busch, S Pati, Howard BM, Callcut RA, Vilardi RF, Redick BJ, Nelson MF, Cohen MJ. J Trauma Acute Care Surg. 2014 Dec;77(6):818-27. 2014

Recombinant factor VIIa enhances platelet deposition from flowing haemophilic blood but requires the contact pathway to promote fibrin deposition. Li R, Panckeri KA, Fogarty PF, Diamond SL. Haemophilia. 2015; 21:266-74.

Postinjury Fibrinolysis Shutdown – Rationale for Selective Tranexamic Acid. Moore, EE, Moore, HB, Gonzalez, E, Chapman, MP, Hansen, KC, Sauaia, A, Silliman, CC, and Banerjee, A: Shock. In Press

Caspase 1- mediated pathway promotes generation of thromboinflammatory microparticles. Rothmeier AS, Marchese P, Petrich BG, Furlan Freguia C, Ginsberg MH, Ruggeri ZM, Ruf W. J Clin Invest 2015;125(4):1471-84.

Histonesinduce phosphatidylserineexposureanda procoagulant phenotype in human red blood cells. Semeraro F, AmmolloCT, EsmonNL, EsmonCT.J Thromb Haemost. 2014 Oct;12(10):1697-702.

Factor V Ia binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. Sundaram J, Keshava S, Gopalakrishnan R, Esmon CT, Pendurthi UR, et al. J Thromb Haemost. 2014 May;12(5):690-700.

Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis. Travers RJ,Shenoi RA,Kalathottukaren MT,Kizhakkedathu JN, Morrissey JH. Blood.2014 Nov 20;124(22):3183-90.

Traumatic brain injury disrupts cerebrovascular tone through endothelial iNOS expression and nitric oxide gain-offunction. Villalba N, Sonkusare SK, Longden TA, Tran TL, Nelson MT, Wellman GC, Freeman K. Journal of the American Heart Association (2014; 2014 Dec 19, 3(6)).

Shock releases bile acid inducing platelet inhibition and fibrinolysis. Wiener G, Moore HB, Moore EE, Gonzalez E, Diamond S, Zhu S, D’Alessandro A, Banerjee A. J Surg Res. 2015 (epub ahead of print).

Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. J Trauma Acute Care Surg. 2014 Dec;77(6):811-7

A principal component analysis of postinjury viscoelastic assays: clotting factor depletion versus fibrinolysis. Chin TL, Moore EE, Moore HB, Gonzalez E, Chapman MP, Stringham JR, Ramos CR, Banerjee A, Sauaia A Surgery. 2014 Sep;156(3):570-7. doi: 10.1016/j.surg.2014.04.030. Epub 2014 Jun 21

Activated clotting time of thrombelastography (T-ACT) predicts early postinjury blood component transfusion beyond plasma. Moore HB, Moore EE, Chin TL, Gonzalez E, Chapman MP, Walker CB, Sauaia A, Banerjee A. Surgery. 2014 Sep;156(3):564-9. doi: 10.1016/j.surg.2014.04.017. Epub 2014 Jun 2.

Plasma first in the field for postinjury hemorrhagic shock. Moore EE, Chin TL, Chapman MC, Gonzalez E, Moore HB, Silliman CC, Hansen KC, Sauaia A, Banerjee A. Shock. 2014 May;41 Suppl 1:35-8

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury inhemorrhagic shock and resuscitation. Ding N, Chen G, Hoffman R, Loughran PA, Sodhi CP, Hackam DJ, Billiar TR, Neal MD. Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.

Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps. Brown JB, Neal MD, Guyette FX, Peitzman AB, Billiar TR, Zuckerbraun BS, Sperry JL. Prehosp Emerg Care. 2015 January-March;19(1):79-86. Epub 2014 Jul 30

Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial. Brown JB, Guyette FX, Neal MD, Claridge JA, Daley BJ, Harbrecht BG, Miller RS, Phelan HA, Adams PW, Early BJ, Peitzman AB, Billiar TR, Sperry JL. Prehosp Emerg Care. 2015 Feb 6. [Epub ahead of print]