What is TACTIC
The TACTIC Research Program (https://www.tacticproject.org), started in September 2013 and includes 10 Basic Science Projects conducted by 14 Investigators across 10 different institutions, in a trans-agency partnership between the National Institutes of Health (NIH) and Department of Defense (DoD). This enterprise was intended to coincide with a large DoD clinical trials program intended to answer therapeutic questions about early administration of plasma and the use of tranexamic acid to block fibrinolysis. The clinical trials will have practical implications on patient care; moreover, they provide the opportunity for standardized acquisition of well-phenotyped clinical samples from civilian trauma patients in the minutes immediately following injury. The TACTIC basic science projects will utilize these biological specimens and clinical information obtained from these civilian trauma patients, along with additional parallel studies in model systems, to advance mechanistic research in TIC.