The TACTIC team was assembled to study coagulation in trauma patients. Trauma induced coagulopathy (TIC) occurs after injury and shock, accompanied by a “storm” of inflammatory and coagulation events leading to incapacitation of the hemostatic process.

What is TIC?

Trauma Induced Coagulopathy (TIC) is an acute disturbance in the ability of the body to create clot which occurs after severe traumatic injury. It can result in excessive and ongoing bleeding which can be difficult to stop. It can complicate traumatic injury in up to 25% of patients and is associated with a higher risk of death following traumatic injury.

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Basic Science

One element of the comprehensive team approach of TACTIC is a set of 10 Basic Science Projects that address the problem of TIC using a composite of in vitro and in vivo approaches to identify candidates responsible for TICs.

 

  • The role of Factor XIa in TIC
  • Platelet function and the hemostatic response in animal models of TIC
  • Identifying the molecular basis for platelet dysfunction in trauma
  • Impaired ADP-induced platelet activation after major trauma
  • Clinical platforms for assessment of coagulation in trauma
  • Inflammatory mechanisms leading to issue factor expression in TIC
  • Trauma-induced endothelial injury and inflammation that results in coagulopathy and end-organ damage
  • Histones and polyphosphate (polyP) involvement in TIC
  • Endothelial barrier function after trauma
  • Effects of histones, polyphosphates and thrombin on native endothelium in trauma

Clinical Trials

TACTIC will interact with researchers engaged in clinical trials involving point-of-care studies and processing of blood samples. These samples will be analyzed by members of the TACTIC group, utilizing new technologies to identify the natural history of TIC events.

 

  • Control of Major Bleeding After Trauma (COMBAT)
    University of Colorado – Denver
  • Prehospital Air Medical Plasma Trial (PAMPer)
    University of Pittsburgh
  • Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP)
  • Mayo